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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
17.88
Human Site:
S215
Identified Species:
24.58
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S215
D
V
G
N
L
L
R
S
H
G
I
D
L
D
H
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S215
D
V
G
N
L
L
R
S
H
G
I
D
L
D
H
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S214
D
V
G
N
L
L
R
S
H
G
I
D
L
D
H
Dog
Lupus familis
XP_535848
1288
147094
S215
D
V
G
N
L
L
R
S
H
G
I
D
L
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
H220
S
H
G
I
D
L
D
H
N
R
F
L
I
L
Q
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
D214
D
R
Y
Q
A
L
K
D
E
V
V
R
A
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
D133
E
K
S
N
K
L
S
D
E
M
K
I
K
N
K
Chicken
Gallus gallus
NP_989849
1274
145838
A236
I
G
S
A
R
L
R
A
P
I
Q
T
L
C
R
Frog
Xenopus laevis
P50532
1290
146971
H216
S
H
G
I
D
L
D
H
N
R
F
L
I
L
Q
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S214
D
V
G
T
L
L
R
S
H
G
I
D
L
D
H
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
H218
S
H
G
I
D
L
D
H
N
R
F
L
I
L
Q
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
E375
S
M
Q
D
L
L
R
E
K
Q
Q
H
V
E
K
Honey Bee
Apis mellifera
XP_396862
1282
148175
N214
K
P
K
A
Q
H
E
N
D
T
G
M
L
E
F
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
H228
R
V
D
I
D
I
E
H
N
R
F
L
I
L
Q
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
K236
E
C
T
A
L
L
R
K
A
G
V
D
L
D
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
Q215
K
I
D
E
L
N
K
Q
L
E
T
L
N
E
S
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
N288
E
V
T
K
L
L
K
N
E
G
I
D
L
D
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
13.3
13.3
N.A.
13.3
20
13.3
93.3
13.3
20
6.6
6.6
53.3
P-Site Similarity:
100
100
100
100
N.A.
26.6
26.6
N.A.
26.6
26.6
26.6
93.3
26.6
46.6
20
26.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
18
6
0
0
6
6
0
0
0
6
0
0
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
0
0
0
6
0
% C
% Asp:
36
0
12
6
24
0
18
12
6
0
0
42
0
42
0
% D
% Glu:
18
0
0
6
0
0
12
6
18
6
0
0
0
18
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
24
0
0
0
6
% F
% Gly:
0
6
48
0
0
0
0
0
0
42
6
0
0
0
0
% G
% His:
0
18
0
0
0
6
0
24
30
0
0
6
0
0
42
% H
% Ile:
6
6
0
24
0
6
0
0
0
6
36
6
24
0
0
% I
% Lys:
12
6
6
6
6
0
18
6
6
0
6
0
6
0
12
% K
% Leu:
0
0
0
0
53
83
0
0
6
0
0
30
53
24
0
% L
% Met:
0
6
0
0
0
0
0
0
0
6
0
6
0
0
0
% M
% Asn:
0
0
0
30
0
6
0
12
24
0
0
0
6
6
0
% N
% Pro:
0
6
0
0
0
0
0
0
6
0
0
0
0
0
0
% P
% Gln:
0
0
6
6
6
0
0
6
0
6
12
0
0
6
24
% Q
% Arg:
6
6
0
0
6
0
48
0
0
24
0
6
0
0
6
% R
% Ser:
24
0
12
0
0
0
6
30
0
0
0
0
0
0
6
% S
% Thr:
0
0
12
6
0
0
0
0
0
6
6
6
0
0
0
% T
% Val:
0
42
0
0
0
0
0
0
0
6
12
0
6
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _